SARS-CoV Spike Protein S1 (SARS1-G241F)
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Description :Recombinant SARS-CoV Spike Protein S1 (14-680) was expressed in CHO cells using a C-terminal human IgG1 Fc tag.
Species :Virus
Tag :Fc tag
Expression System:CHO cells
Sequence :14-680
Genbank Number : AY278554
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Assay Data :Binding ability measured in a functional ELISA. Anti-2019-nCoV Spike Protein (C19S1-61H) binds to immobilized SARS-CoV Spike Protein S1 (Fc tag).
Assay Data :Binding ability measured in a functional ELISA. Immobilized human ACE2(19-740) protein (Fc tag) (A51C2-G341F) can bind to SARS-CoV Spike Protein S1 (Fc tag).
Molecular Weight :150 kDa
Gene Aliases :SARS coronavirus S1, coronavirus S2, coronavirus spike, cov spike, ncov S1, ncov S2.
Scientific Background :The severe acute respiratory syndrome related novel coronavirus (SARS-CoV) has caused the 2002-2003 SARS epidemic that broke out in southern China, which spread to other regions of Asia, Europe and North America (1). The spike glycoprotein (S) of coronavirus belongs to the type I transmembrane protein containing two subunits, S1 and S2 (2), which is also known to be the key component to bind with host cells through the interaction with angiotensin-converting enzyme 2 (ACE2). SARS-CoV can specifically recognize ACE2 through its receptor binding domain (RBD) of S1 to initiate viral infection in humans (3).
References :
1.Li F, et al: Receptor recognition and cross-species infections of SARS coronavirus. Antiviral Research. 2013, 100 (1): 246-254.
2.Xiao X, et al: The SARS-CoV S glycoprotein. Cell Mol Life Sci. 2004, 61 (19-20): 2428-30.
3.Wan Y, et al: Receptor Recognition by the novel Coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS Coronavirus. Journal of virology. 2020: 94.
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