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Description :Rabbit Polyclonal Antibody

Species :

Tag :

Expression System:

Sequence :

Specificity :Recognizes the Stathmin protein

Cited Applications :WB, ELISA, IF, IHC

Cross Reactivity :Human and Mouse

Host / Isotype / Clone# :Rabbit, IgG

Immunogen :Stathmin antibody was raised against a 20 amino acid synthetic peptide from near the carboxy terminus of human Stathmin

Purification :Affinity chromatography

Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Sample Data :Western blot analysis of Stathmin in EL4 cell lysate with Stathmin antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.

Sample Data :Immunohistochemistry of Stathmin in human brain tissue with Stathmin antibody at 2.5 ug/mL.

Scientific Background :Stathmin is a ubiquitous, highly conserved protein present in the cytoplasm in a variety of unphosphorylated and phosphorylated forms. Stathmin functions as an intracellular relay integrating regulatory signals of the cellular environment (1). Stathmin is involved in the regulation of the microtubule filament system. Stathmin binds tubulin in a ternary complex, with 2 tubulins for every stathmin and this complex interferes with microtubule dynamics in vitro and in vivo. Overexpression of several stathmin mutants suggest that stathmin induces depolymerization of interphase and mitotic microtubules in its unphosphorylated state, but is inactivated by phosphorylation in mitosis (2).

References :
1. Sobel, A. Stathmin: a relay phosphoprotein for multiple signal transduction? Trends Biochem. Sci. 16: 301-305, 1991.

2. Gavet, O. et al: The stathmin phosphoprotein family: intracellular localization and effects on the microtubule network. J. Cell Sci. 111: 3333-3346, 199.

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Research Areas :Cancer, Invasion/Metastasis, Neurobiology, Cancer, Neurobiology, Invasion/Metastasis