STK39 (STLK3), Active(S51-10H)
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Description :Recombinant full-length human STK39 (STLK3) was expressed using baculovirus in Sf9 insect cells using an N-terminal His tag.
Species :Human
Tag :HIS tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :NM_013233
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~63 kDa
Gene Aliases :STK39; STLK3; DCHT; DKFZp686K05124; PASK; SPAK
Scientific Background :STK39 (also known as serine threonine kinase 39) is involved in the cellular stress response pathway. STK39 is activated in response to hypotonic stress leading to phosphorylation of several cation-chloride-coupled co-transporters. STK39 activates the p38 MAP kinase pathway and its interaction with p38 decreases during cellular stress (1). STK39 acts as an intermediate in the response to cellular stress. STK39 is also an independent risk factor for hypertension in men and its intragenic SNPs can interact and function in the control of blood pressure (2).
References :
1. Johnston, A. M. et.al: SPAK, a STE20/SPS1-related kinase that activates the p38 pathway. Oncogene 19: 4290-4297, 2000.
2. Chen LY. et.al: STK39 is an independent risk factor for male hypertension in Han Chinese. Int J Cardiol, 2010 Oct 1.
Product Sheets (By Lot #) :
Research Areas :Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, PKA/PKC Pathway, Ser/Thr Kinases, Neurobiology, Cardiovascular Disease, ERK/MAPK Pathway, PKA/PKC Pathway, Ser/Thr Kinases