STK35 (CLIK1) Protein(S47-35G)
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Description :Recombinant human STK35 (CLIK1) (134-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :134-end
Genbank Number :NM_080836
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~70 kDa
Gene Aliases :CLIK1; STK35L1
Scientific Background :STK35 is serine/threonine kinase 35 which is a kinase that is predominantly found in the nucleus and interacts with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. STK35 protein is a regulator of actin stress fibers in nonmuscle cells. STK35 specifically targets STK1 to actin stress fibers and that it may represent a regulator of the actomyosin cytoskeleton in nonmuscle cells (1).
References :
1. Vallenius, T. et.al: Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein. J. Cell Sci. 115: 2067-2073, 2002.
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Research Areas :Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, PKA/PKC Pathway, Ser/Thr Kinases, Neurobiology, Cardiovascular Disease, ERK/MAPK Pathway, PKA/PKC Pathway, Ser/Thr Kinases