TSSK1B, Active(S40-10BG)
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Description :Recombinant full-length human TSSK1B was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :NM_032028
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~71 kDa
Gene Aliases :TSSK1, STK22D, FKSG81, SPOGA4
Scientific Background :TSSK1B (testis-specific serine kinase 1B) is a member of a unique subfamily of protein kinases belonging to the AMPK branch on the human kinome tree. TSSK1B is a serine/threonine kinases that is highly expressed in testis and lower express in pancreas, and weak expression in a few other tissues. TSSK members are present in the equatorial segment of human sperm. TSSK1B share 72% amino acid identity and 83% identity in the kinase domain with other family TSSK members and the TSSK1 gene is intronless. In vitro kinase assay shows phosphorylation of TSKS by TSSK1 and TSSK2.
References :
1. Hao, Z. et.al: Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues: a TSSK member is present in the equatorial segment of human sperm.
2. Xu, B. et al: Validation of a testis specific serine/threonine kinase [TSSK] family and the substrate of TSSK1 & 2, TSKS, as contraceptive targets. Soc Reprod Fertil Suppl. 2007;63:87-101.
Product Sheets (By Lot #) :
Research Areas :Cancer, Cardiovascular Disease, Ser/Thr Kinases, Cancer, Cardiovascular Disease, Ser/Thr Kinases