DRAK2 (STK17B), Active(S34-10G)
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Description :Recombinant full-length human DRAK2 (STK17B) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :NM_004226
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~69 kDa
Gene Aliases :DRAK2; STK17B
Scientific Background :DRAK2 is a member of the serine/threonine kinase family and is related to death-associated protein kinase that triggers apoptosis (1). DRAK2 is selectively important for T-cell survival and inhibition of DRAK2 has therapeutic potential for autoimmune disease (2). T-cell survival depends on a balance of T-cell receptor and co-stimulatory signals and deficiency of DRAK2 can affect autoimmune disease susceptibility without generalized suppression of the immune system (3).
References :
1. Sanjo, H. et.al: DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. J. Biol. Chem. 273: 29066-29071, 1998.
2. Ramos, S. J. et.al: Enhanced T cell apoptosis within Drak2-deficient mice promotes resistance to autoimmunity. J. Immun. 181: 7606-7616, 2008.
3. McGargill, M. A. et.al: Drak2 regulates the survival of activated T cells and is required for organ-specific autoimmune disease. J. Immun. 181: 7593-7605, 2008.
Product Sheets (By Lot #) :
Research Areas :Apoptosis/Autophagy, Metabolic Disorder, Ser/Thr Kinases, Metabolic Disorder, Apoptosis/Autophagy, Ser/Thr Kinases