Anti-SUMO3(S295-63R)
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Description :Rabbit Polyclonal Antibody
Species : Rabbit, IgG
Specificity: Recognizes the SUMO3 protein
Cited Applications :WB, ELISA, IF, IHC
Cross Reactivity :Human, Mouse and Rat
Host / Isotype / Clone# :Rabbit, IgG
Immunogen :SUMO3 antibody was raised against a 13 amino acid synthetic peptide near the carboxy terminus of human SUMO3.
Purification :Affinity chromatography
Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Western blot analysis of SUMO3 in mouse liver tissue lysate with SUMO3 antibody at (A) 1 ug/ml and (B) 2 ug/ml.
Sample Data :Immunohistochemistry of SUMO3 in rat liver tissue with SUMO3 antibody at 5 ug/ml.
Scientific Background :SUMO3 is a member of the SUMO (small ubiquitin-like modifier) protein family which functions in a manner similar to ubiquitin. SUMO3 is bound to target proteins as part of a post-translational modification system and modifies numerous cellular proteins and affect their metabolism and function. SUMO3 is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability (1). SUMO3 predominantly detected in the cytoplasm (2).
References :
1. Su, H.-L. et.al: Molecular features of human ubiquitin-like SUMO genes and their encoded proteins. Gene 296: 65-73, 2002.
2. Lapenta, V.et.al: SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family. Genomics 40: 362-366, 1997.
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Research Areas :Apoptosis/Autophagy, Cell Cycle, NfkB Pathway, NfkB Pathway, Apoptosis/Autophagy, Cell Cycle