Anti-SUMO2/3(S294-63BR)
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Description :Rabbit Polyclonal Antibody
Species :
Tag :
Expression System:
Sequence :
Specificity :Recognizes the SUMO2/3 protein
Cited Applications :WB, ELISA, IF, IHC
Cross Reactivity :Human, Mouse and Rat
Host / Isotype / Clone# :Rabbit, IgG
Immunogen :SUMO2/3 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human SUMO2.
Purification :Affinity chromatography
Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Western blot analysis of SUMO2/3 in rat liver tissue lysate with SUMO2/3 antibody at (A) and (B) 2 ug/ml.
Sample Data :Immunohistochemistry of SUMO2/3 in rat liver tissue with SUMO2/3 antibody at 5 ug/ml.
Scientific Background :SUMO2 and 3 are members of the SUMO (small ubiquitin-like modifier) protein family which functions in a manner similar to ubiquitin. SUMO 3 is bound to target proteins as part of a post-translational modification system and modifies numerous cellular proteins and affect their metabolism and function. SUMO 2 and 3 are involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability (1). SUMO3 predominantly detected in the cytoplasm (2). and SUMO2 is predominantly detected in nuclear bodies.
References :
1. Su, H.-L. et.al: Molecular features of human ubiquitin-like SUMO genes and their encoded proteins. Gene 296: 65-73, 2002.
2. Kamitani, T. et.al: Characterization of a second member of the sentrin family of ubiquitin-like proteins. J. Biol. Chem. 273: 11349-11353, 1998.
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Research Areas :Apoptosis/Autophagy, Cell Cycle, NfkB Pathway, Apoptosis/Autophagy, Cell Cycle, NfkB Pathway, NfkB Pathway, Apoptosis/Autophagy, Cell Cycle