Anti-SUMO1(S293-63R)
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Description :Rabbit Polyclonal Antibody
Species :
Tag :
Expression System:
Sequence :
Specificity :Recognizes the SUMO1 protein
Cited Applications :WB, ELISA, IF, IHC
Cross Reactivity :Human, Mouse and Rat
Host / Isotype / Clone# :Rabbit, IgG
Immunogen :SUMO1 antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human SUMO1
Purification :Affinity chromatography
Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Western blot analysis of SUMO1 in HL-60 cell lysate with SUMO1 antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.
Sample Data :Immunocytochemistry of SUMO1 in HL60 cells with SUMO1 antibody at 5 ug/ml.
Scientific Background :SUMO1 (also known as UBL1) is a member of the SUMO (small ubiquitin-like modifier) protein family which functions in a manner similar to ubiquitin. SUMO1 is bound to target proteins as part of a post-translational modification system and it is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability (1). SUMO1 may be involved in the repair of TOP1-mediated DNA damage (2). The sumoylation pathway plays a significant role in mammalian DNA damage response.
References :
1. Su, H.-L. et.al: Molecular features of human ubiquitin-like SUMO genes and their encoded proteins. Gene 296: 65-73, 2002.
2. Mao, Y. et.al: SUMO-1 conjugation to topoisomerase I: a possible repair response to topoisomerase-mediated DNA damage. Proc. Nat. Acad. Sci. 97: 4046-4051, 2000.
Product Sheets (By Lot #) :
Research Areas :Apoptosis/Autophagy, Cell Cycle, NfkB Pathway, NfkB Pathway, Apoptosis/Autophagy, Cell Cycle