SUMO1 (UBL1) Protein(S293-31H)

SUMO1 (UBL1) Protein(S293-31H)

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Description :Recombinant human SUMO1 (UBL1) (2-97) was expressed in E. coli cells using an N-terminal His tag.

Species :Human

Tag :HIS tag

Expression System:E.coli

Sequence :2-97

Genbank Number :NM_003352

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Western Blot

Molecular Weight :~19 kDa

Gene Aliases :UBL1; DAP1; GMP1; SMT3; OFC10; SENP2; SMT3C; SMT3H3; PIC1

Scientific Background :SUMO1 (also known as UBL1) is a member of the SUMO (small ubiquitin-like modifier) protein family which functions in a manner similar to ubiquitin. SUMO1 is bound to target proteins as part of a post-translational modification system and it is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability (1). SUMO1 may be involved in the repair of TOP1-mediated DNA damage (2). The sumoylation pathway plays a significant role in mammalian DNA damage response.

References :
1. Su, H.-L. Molecular features of human ubiquitin-like SUMO genes and their encoded proteins. Gene 296: 65-73, 2002.

2. Mao, Y. SUMO-1 conjugation to topoisomerase I: a possible repair response to topoisomerase-mediated DNA damage. Proc. Nat. Acad. Sci. 97: 4046-4051, 2000.

Product Sheets (By Lot #) :


Research Areas :Apoptosis/Autophagy, Cell Cycle, NfkB Pathway, NfkB Pathway, Apoptosis/Autophagy, Cell Cycle