Anti-phospho-STK10-a (Ser482 Ser486 Ser490)(S29-165R)
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Description :Rabbit Polyclonal Antibody
Species :Rabbit
Tag :
Expression System:
Sequence :
Specificity :Recognizes the STK10-a protein phosphorylated at serine 482/486/490
Cited Applications :WB
Cross Reactivity :Human, Mouse, Rat and Zebrafish
Host :Rabbit, IgG
Immunogen :Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser482/486/490 conjugated to KLH
Purification :Affinity Chromatography
Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Scientific Background :Polo-like kinase (PLK) plays an important role in cell cycle regulation. PLK is also required for bipolar spindle formation, activation of the anaphase-promoting complex/cyclosome, and cytokinesis. Deregulation of PLKs often results in abnormalities in centrosome duplication, maturation and/or microtubule dynamics (1). STK10-a, which is also known as PLKK is likely responsible for activating PLK. STK10-a itself is activated by phosphorylation at Ser482, Ser486 and Ser490 (2).
References :
1. Nigg, EA. et al: Dynamic changes in nuclear architecture during mitosis: on the role of protein phosphorylation in spindle assembly and chromosome segregation. Exp Cell Res. 1996 Dec 15;229
2. Erikson E et al. A feedback loop in the polo-like kinase activation pathway. J Biol Chem. 2004, 279:32219-32224.
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Research Areas :Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, PKA/PKC Pathway, Ser/Thr Kinases, Neurobiology, Cardiovascular Disease, ERK/MAPK Pathway, PKA/PKC Pathway, Ser/Thr Kinases