Alpha Synuclein Antibody(S22-62R)

Alpha Synuclein Antibody(S22-62R)

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Description :Rabbit Polyclonal Antibody

Genbank Number :NM_020630

Cited Applications :WB (1:1000); IHC; ELISA
Ideal working dilutions for each application should be empirically determined by the investigator.

Specificity :Detects ~14.46 kDa.

Cross Reactivity :Human, Mouse, Rat

Host :Rabbit

Immunogen :Recombinant Human alpha Synuclein Fibril

Formulation :PBS, pH 7.4, 50% glycerol, 0.09% sodium azide.

Stability :1yr at –200C from date of shipment. Avoid freeze/thaw cycle.

Scientific Background :Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).

References :1. “Genetics Home Reference: SNCA”. US National Library of Medicine. (2013).
2. Zhang L., et al. (2008) Brain Res. 1244: 40-52.
3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117.
4. Kokhan V.S., Afanasyeva M.A., Van'kin G. (2012) Behav. Brain. Res. 231(1): 226-230.
5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840.
6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757.

Sample Data :Western Blot analysis of Human Recombinant Protein showing detection of Alpha Synuclein protein using Rabbit Alpha Synuclein Polyclonal Antibody (Cat# S22-62R). Lane 1: MW ladder. Lane 2: Alpha Synuclein. Lane 3: Beta Synuclein. Lane 4: Gamma Synuclein. Alpha synuclein antibody shows cross-reactivity with beta synuclein but not gamma synuclein.

Sample Data :Western blot analysis of Human Truncated Alpha Synuclein Portien showing detection of Alpha Synuclein protein using Rabbit Alpha Synuclein Polyclonal Antibody (Cat# S22-62R). Lane 1: MW ladder. Lane 2: hASYN aa 1-114 (5 µL).

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E4198-21.pdf

Research Areas :Cancer