Alpha synuclein Pre-Formed Fibril (Type 2)(S22-382N)

Alpha synuclein Pre-Formed Fibril (Type 2)(S22-382N)

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Description :Recombinant full-length tag-free human Alpha-synuclein Pre-Formed Fibril (Type 2) was expressed in E. coli cells.

Species :Human

Tag :TAG-Free

Expression System:E.coli

Sequence :Full Length

Genbank Number :NP_000336.1

Alternative Names :Alpha synuclein aggregates; Non-A beta component of AD amyloid protein; Non-A4 component of amyloid precursor protein; NACP protein

Formulation :Recombinant protein stored in PBS.

Storage and Stability :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Scientific Background :Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson’s disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).

References :1. “Genetics Home Reference: SNCA”. US National Library of Medicine. (2013).
2. Zhang L., et al. (2008) Brain Res. 1244: 40-52.
3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117.
4. Kokhan V.S., Afanasyeva M.A., Van’kin G. (2012) Behav. Brain. Res. 231(1): 226-230.
5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840.
6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757.

Sample Data :SDS-PAGE of ~14 kDa Human Recombinant Alpha Synuclein Protein Pre-Formed Fibrils (Type 2) (Cat# S22-382N). Lane 1: Molecular Weight Ladder (MW). Lane 2: Alpha Synuclein Pre-Formed Fibrils (Cat# S22-382N).

Sample Data :TEM of Alpha Synuclein Pre-Formed Fibrils (Type 2) (Cat# S22-382N).

Product Sheets (By Lot #) :

E4198-26.pdf

Research Areas :Neurobiology