Anti-SNCA(S22-360M)
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Description :Mouse Monoclonal Antibody
Species :Mouse
Tag :
Expression System:
Sequence :
Specificity :Recognizes the SNCA protein
Cited Applications :WB, IF
Cross Reactivity :Human, Mouse and Rat
Host :Mouse, IgG1, 3H9
Immunogen :Full length human alpha synuclein expressed in E. Coli.
Purification :Ascites fluid
Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Western blot of rat brain lysate showing specific immunolabeling of the ~ 15kDa SNCA protein.
Sample Data :Mixed neuron-glial cultures stained with Anti-SNCA (red) and chicken Anti-MAP2 (green). The Anti-SNCA antibody stains vesicular structures, the perikarya and processes of the neurons in this image.
Scientific Background :Alpha-synuclein is expressed in the presynaptic terminal of the neuron where it is implicated in the formation of SNARE complexes. Aggregated alpha-synuclein is one of the major components found in the Lewy bodies, which are found in the brains of patients with Parkinson’s disease (PD) and other neurodegenerative disorders (1). In fact, there is evidence to suggest that early onset Parkinson's disease may be caused by a duplication or triplication of one of the alpha synuclein genes (2). Alpha-synuclein is also found in the brains of patients with multiple system atrophy (MSA) and amyotrophic lateral sclerosis (ALS).
References :
1. Okochi, M. et al: Constitutive phosphorylation of the Parkinson’s disease associated alpha-synuclein. J Biol Chem 2000 Jan 7;275(1): 390-7.
2. Chartier-Harlin, M C. et al: Alpha-synuclein locus duplication as a cause of familial Parkinson's disease. Lancet 2004 364: 1167-1169.
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Research Areas :Cancer, Neurobiology, Cancer, Neurobiology