SNRK, Active(S16-10G)
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Description :Full-length recombinant human SNRK was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :NM_017719
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~110 - 120 kDa
Gene Aliases :HSNFRK, SNFRK, KIAA0096
Scientific Background :SNRK or sucrose non-fermenting related kinase is a member of the sucrose nonfermenting (SNF)-related kinase family of serine/threonine kinases which acts as a kinase and displays autophosphorylation activity (1). SNRK act as a substrate for the LKB1 tumor suppressor which phosphorylated SNRK at residue thr173 in which LKB1 is required for phosphorylation and activation of SNRK in HeLa cells and required STRAD and MO25 LKB1 complex-associated subunits. Snrk-1 is involved in multiple steps of angioblast development and acts via notch signaling pathway in artery-vein-specification in vertebrates (2).
References :
1. Kertesz, N. et.al: Cloning and characterization of human and mouse SNRK sucrose non-fermenting protein (SNF-1)-related kinases. Gene 294: 13-24, 2002.
2. Chun, C. Z. et.al: Snrk-1 is involved in multiple steps of angioblast development and acts via notch signaling pathway in artery-vein-specification in vertebrates. Blood 113: 1192-1199, 2009.
Product Sheets (By Lot #) :
Research Areas :Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Metabolic Disorder, Ser/Thr Kinases, Cancer, Inflammation, Metabolic Disorder, Cardiovascular Disease, Apoptosis/Autophagy, Ser/Thr Kinases