Anti-SH2D1A (SAP)(S03-63R)

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Description :Rabbit Polyclonal Antibody

Species :

Tag :

Expression System:

Sequence :

Specificity :Recognizes the SH2D1A (SAP) protein

Cited Applications :WB

Cross Reactivity :Western blot human SH2D1A (SAP)

SH2D1A (SAP) from other species may also be detectable.

Host  :Rabbit

Immunogen :Synthetic peptide corresponding to amino acids 113-128 of human SH2D1A (SAP)

Purification :Affinity chromatography

Stability :Store at 4^oC (add 0.1% NaN₃) for several months, and at -20^oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For optimal performance, avoid repeated handling and multiple freeze/thaw cycles.

Sample Data :Representative Western blot with Anti-SH2D1A (SAP) (1:1000) using 15 μg, 30 μg and 60 μg of Jurkat cell lysate.

Scientific Background :SH2D1A contains an SH2 domain and a short tail, and expresses at a high level in thymus and lung. It acts as an inhibitor of the SLAM (signaling lymphocyte-activation molecule) proteins by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. It modifies signal transduction pathways in activated T, B and NK cells. SH2D1A mediates interaction between FYN and SLAMF1 (1). Mutations in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) (2).

References :
1. Chan B., et al: SAP couples Fyn to SLAM immune receptors. Nat. Cell Biol. 5:155-160(2003)

2. Dutz, J. P., et al: Lymphocytic vasculitis in X-linked lymphoproliferative disease. Blood 97: 95-100, 2001.

Product Sheets (By Lot #) :

M132-9.pdf

Research Areas :Inflammation, Inflammation