SCYL2 Protein(S03-35G)

SCYL2 Protein(S03-35G)

  • $215.00


Description :Recombinant human SCYL2 (1-520) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :1-520

Genbank Number :NM_017988

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Western Blot

Molecular Weight :~84 kDa

Gene Aliases :CVAK104, KIAA1360

References :
1. Borner GH. CVAK104 is a novel regulator of clathrin-mediated SNARE sorting. Traffic. 2007 Jul;8(7):893-903.

2. Miyakawa K. Interferon-induced SCYL2 limits release of HIV-1 by triggering PP2A-mediated dephosphorylation of the viral protein Vpu. Sci Signal. 2012 Oct 9;5(245):ra73. doi: 10.1126/scisignal.2003212

Scientific Background :SCYL2 or SCY1-like 2 (S. cerevisiae) is an evolutionarily conserved protein involved in SNARE sorting that is essential for normal embryonic development (1). SCYL2 serves as a regulatory factor for Vpu (viral protein U) which reducing the extent of Vpu phosphorylation and consequently enhancing BST2-mediated viral restriction (2).

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Research Areas :Inflammation, Invasion/Metastasis, Neurobiology, Neurobiology, Inflammation, Invasion/Metastasis