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RSK2 (Y483C), Active(R17-12DG)

RSK2 (Y483C), Active(R17-12DG)

  • $226.00


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Description :Recombinant full-length human RSK2 (Y483C) mutant was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full length (Y483C)

Genbank Number :NM_004586

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay

Molecular Weight :~112 kDa

Gene Aliases :RPS6KA3; HU-3; MAPKAPK1B; CLS; MRX19; ISPK-1; p90-RSK2; pp90RSK2; S6K-alpha3

Scientific Background :RSK2 is a member of the RSK (ribosomal S6 kinase) family that consists of growth factor-regulated serine/threonine kinases. RSK2 has been shown to mediate growth factor signaling via RAS and MAPK leading to the induction of CREB serine-133 phosphorylation and activation of gene expression (1). Mutations in RSK2 have been shown to be responsible for Coffin-Lowry syndrome (CLS) which is a X-linked disorder characterized by severe psychomotor retardation, facial and digital dysmorphisms, and progressive skeletal deformations (2).

References :
1. Xing, J. et al: Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science. 1996 Aug 16;273(5277):959-63.

2. Jacquot, S. et al: Mutation analysis of the RSK2 gene in Coffin-Lowry patients: extensive allelic heterogeneity and a high rate of de novo mutations. Am J Hum Genet. 1998 Dec;63(6):1631-40.

Product Sheets (By Lot #) :

O976-2.pdf

Research Areas :Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Inflammation, Neurobiology, NfkB Pathway, Ser/Thr Kinases, Cancer, Neurobiology, Inflammation, Cardiovascular Disease, ERK/MAPK Pathway, NfkB Pathway, Apoptosis/Autophagy, Ser/Thr Kinases