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Roscovitine(C22-901)

Roscovitine(C22-901)

  • $83.00


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Description :p34/CDC2 inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :186692-46-6

Molecular Formula :C19H26N6O

Appearance :White solid

Melting Point :N/A

Molecular Weight :354.5

Purity :>99% (TLC); NMR (Conforms)

Solubilization :May be dissolved in Ethanol (10mg/ml) or DMSO (10mg/ml, warm)

Aliases :(R)-2-((6-(benzylamino)-9-isopropyl-9H-purin-2-yl) amino) butan-1-ol

Storage and Stability :Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 3 months.

Scientific Background :Potent and selective inhibitor of cyclin-dependent kinases displaying higher potency and selectivity compared to olomoucine. p34 cdc2 IC50 = 0.2 uM. Also inhibits p33cdk2 and p33cdk5. Anti-angiogenic. Cell permeable.

References :
1. L Meijer et al. Eur. J. Biochem. 1997 243:527

2. J Liebl et al. Angiogenesis 2011 14:281

Molecular Structure :

Product Sheets (By Lot #) :

T2257-64.pdf

Research Areas :Cancer, Neurobiology, Inflammation, ERK/MAPK Pathway, Invasion/Metastasis