ROR1, Active(R12-11G)

ROR1, Active(R12-11G)

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Description :Recombinant human ROR1(429-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :429-end

Genbank Number :NM_005012

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~82 kDa

Gene Aliases :dJ537F10.1; NTRKR1

Scientific Background :ROR1 is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors that play a role in the control of most basic cellular processes including cell proliferation, differentiation, migration and metabolism (1). Many human breast cancers express the ROR1 protein and high-level expression of ROR1 in breast adenocarcinoma is associated with aggressive disease. Silencing expression of ROR1 in human breast cancer cell lines found to express this protein impaired their growth in vitro and also in immune-deficient mice (2).

References :
1. Afzal, A. R. et.al: One gene, two phenotypes: ROR2 mutations in autosomal recessive Robinow syndrome and autosomal dominant brachydactyly type B. Hum. Mutat. 22: 1-11, 2003.

2. Zhang, S. et al: ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth. PLoS One. 2012;7(3):e31127.

Product Sheets (By Lot #) :

F748-3.pdf

F519-3.pdf

Research Areas :Cancer, Cardiovascular Disease, Invasion/Metastasis, Neurobiology, Receptor Tyrosine Kinases, WNT Signaling, Cancer, Neurobiology, Cardiovascular Disease, WNT Signaling, Invasion/Metastasis, Receptor Tyrosine Kinases