Romidepsin (FK228)(H83-904I)

Romidepsin (FK228)(H83-904I)

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Description :HDAC Inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :128517-07-7

Molecular Formula :C24H36N4O6S2

Appearance :Colorless lyophilized wax. (note, vials appear empty)

Molecular Weight :540.7

Purity :>98% (HPLC)

Solubilization :May be dissolved in DMSO (10 mg/ml)

Aliases :Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3-5) disulfide

Storage and Stability :Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 1 month.

Scientific Background :A potent and selective inhibitor of class I histone deacetylases (HDACs), IC50 = 36, 47, 510 and 14,000 nM for HDAC1, 2, 4 and HDAC6, respectively1. Induces apoptosis in a variety of cell lines2 and displays antitumor activity in mouse models3. Recently approved for clinical use in T-cell lymphoma4.

References :
1. R Furumai et al. Cancer Res. 2002 62:4916

2. J Panicker et al. Cell Cycle 2010 9:1830

3. H Ueda et al. J. Antibiot. (Tokyo) 1994 47:315

4. MK VanderMolin et al. J. Antibiot. (Tokyo) 2011 64:525

Molecular Structure :

Product Sheets (By Lot #) :

P3320-33.pdf

Research Areas :Cancer, Cell Cycle, Inflammation