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Ro 31-6045(R21-901)

Ro 31-6045(R21-901)

  • $83.00


Description :Protein Kinase p70 (S6K) inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :113963-68-1

Molecular Formula :C21H15N3O2

Appearance :Orange powder

Molecular Weight :341.4

Purity :>98% (HPLC, TLC); NMR (conforms)

Solubilization :May be dissolved in DMSO (35 mg/ml); or ethanol (9 mg/ml)

Aliases :1-Methyl-3,4-bis(indol-3-yl)maleimide; Bisindolylmaleimide V; BIM V

Storage and Stability :Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 3 months.

Scientific Background :This bis indolylmaleimide derivative is a potent inhibitor of the mitogen-stimulated protein kinase p70 (S6K) acting independently of its upstream activator mTOR1. Does not inhibit PKC (at concentrations <100 µM) and therefore may also be used as a negative control for bisindolylmaleimide PKC inhibitors2 such as GF 109203X3 and other structurally related inhibitors4

References :
1. N Marmy-Conus et al. FEBS Lett. 2002 519:135

2. CS Harmon et al. Skin Pharmacol. 1997 10:71

3. D Toullec et al. J. Biol. Chem. 1991 266:15771

4. PD Davis et al. J. Med. Chem. 1992 35:177

Molecular Structure :

Product Sheets (By Lot #) :


Research Areas :AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Metabolic Disorder, Ser/Thr Kinases