Due to Xmas holidays, our last days of shipping will be as follow: International Dec 18, 2020. USA: Dec 21, 2020. The shipments will resume as usual on International: Jan 8, 2021 and USA: Jan 4, 2021.
RIPK3, Active(R09-10G)

RIPK3, Active(R09-10G)

  • $226.00


FOR BULK ORDER REQUESTS PLEASE CONTACT US

Description :Recombinant full-length human RIPK3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full Length

Genbank Number :NM_006871

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~96 kDa

Gene Aliases :RIP3

Scientific Background :RIPK3 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, which contains a C-terminal domain unique from other RIP family members. RIPK3 is predominantly localized to the cytoplasm, and specifically, are colocalized in the mitochondrion which can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals (1). RIPK3 is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor and caspase-8 prevents RIPK3-dependent necrosis without inducing apoptosis by functioning in a proteolytically active complex with CFLAR and that this complex is required for the protective function (2).

References :
1. Kasof, G. M.et.al: The RIP-like kinase, RIP3, induces apoptosis and NF-kappa-B nuclear translocation and localizes to mitochondria. FEBS Lett. 473: 285-291, 2000.

2. Oberst, A. et.al: Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature 471: 363-367, 2011.

Product Sheets (By Lot #) :

X718-3.pdf

O974-1.pdf

O927-1.pdf

Z1166-1.pdf

Z1382-3.pdf

G1426-2.pdf

K1648-5.pdf

U1775-5.pdf

M2697-7.pdf

E3129-8.pdf

N3602-3.pdf

N3567-4.pdf

N3617-4.pdf

S3392-11.pdf

Research Areas :Apoptosis/Autophagy, Cancer, Inflammation, JAK/STAT Pathway, JNK/SAPK Pathway, p38 Pathway, Ser/Thr Kinases, Cancer, Inflammation, p38 Pathway, JNK/SAPK Pathway, JAK/STAT Pathway, Apoptosis/Autophagy, Ser/Thr Kinases