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RHEB Protein(R42-30H)

RHEB Protein(R42-30H)

  • $215.00


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Description :Recombinant full-length human RHEB was expressed using baculovirus in Sf9 cells using a N-terminal His tag.

Species :Human

Tag :HIS tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full Length

Genbank Number :NM_005614

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~21 kDa

Gene Aliases :RHEB2, MGC111559, Ras Homolog Enriched in Brain

Scientific Background :RHEB is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. RHEB is vital in the regulation of growth and cell cycle progression. RHEB has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form. Drosophila RHEB is a direct target of Tsc2 GTPase-activating protein (GAP) activity both in vivo and in vitro. Point mutations in the Drosophila RHEB gene inhibits cell growth while overexpression promotes cell growth. RHEB functions downstream of Tsc1 and Tsc2 in the mTOR signaling pathway.

References :
1. Stocker, H. et al: Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nature Cell Biol. 5: 559-565, 2003.

2. Zhang, Y. et al: Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nature Cell Biol. 5: 578-581, 2003.

Product Sheets (By Lot #) :

L316-1.pdf

I098-3.pdf

Research Areas :Cancer, Neurobiology, Cardiovascular Disease, ERK/MAPK Pathway, Apoptosis/Autophagy, Angiogenesis, Invasion/Metastasis, Cancer, Neurobiology, Cardiovascular Disease, ERK/MAPK Pathway, Apoptosis/Autophagy, Angiogenesis, Invasion/Metastasis