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RG-108(D353-904C)

RG-108(D353-904C)

  • $50.00


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Description :DNA Methyltransferase Inhibitor

Species :

Tag :

Expression System:

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CAS Registry Number :48208-26-0

Molecular Formula :C19H14N2O4

Appearance :Tan powder

Melting Point :104oC

Molecular Weight :334.3

Purity :>98% (TLC)

Solubilization :May be dissolved in DMSO (100 mg/ml); or ethanol (100 mg/ml)

Aliases :N-Phthalyl-L-tryptophan

Storage and Stability :Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 1 month.

Scientific Background :A non-nucleoside DNA methyltransferase inhibitor. IC50=115 nM1 Inhibits DNA methylation in human tumor cell lines without toxicity2. Enhances the reversion of neural progenitor cells to the pluripotent state3.

References :
1. B Brueckner et al. Cancer Res. 2005 65:6305

2. C Stresemann et al. Cancer Res. 2006 66:2794

3. I Szablowska-Gadomska et al. Acta Neurobiol Exp. 2012 72:337

Molecular Structure :

Product Sheets (By Lot #) :

P3320-31.pdf

Research Areas :Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology