Regorafenib(K01-900)

Regorafenib(K01-900)

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Description :Multi-kinase inhibitor (Including KDR-Tie2)

Species :

Tag :

Expression System:

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CAS Registry Number :835037-03-7

Molecular Formula :C21H15ClF4N4O3

Appearance :Off-White powder

Molecular Weight :482.80

Purity :>98% (HPLC,TLC); NMR (conforms)

Solubilization :May be dissolved in DMSO (50 mg/ml)

Aliases :4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide; BAY 73-4506

Storage and Stability :Store desiccated as supplied at -20oC for up to 2 year. Store solutions at -20oC for up to 3 months.

Scientific Background :A multi-kinase inhibitor related to sorafenib1. Inhibits c-Raf, B-Raf, VEGFR1, VEGFR2, VEGFR3, Tie2, PDGFRβ; FGFR1, c-Kit, and RET with IC50s=2.5, 28, 13, 4.2, 46, 311, 22, 202, 7 and 1.5 nM respectively1-2

References :
1. SM Wilhelm et al. Int. J. Cancer 2011 129:245

2. JCM Uitdehaag et al. PLoS One 2014 9(3):e92146

Molecular Structure :

Product Sheets (By Lot #) :

D3905-3.pdf

Research Areas :AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Inflammation, p38 Pathway, Receptor Tyrosine Kinases