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Description :Full-length recombinant human RBBP5 was expressed in E. coli cells using an N-terminal His tag.
Tag :His tag
Sequence :Full length
Genbank Number :NM_005057
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Methyltransferase Assay
Molecular Weight :~72 kDa
Gene Aliases :RBQ3; SWD1
Scientific Background :Retinoblastoma-binding protein 5 (RBBP5) is believed to play a crucial role in the differentiation potential, particularly along the neural lineage in embryonic stem (ES) cells, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and tri-methylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.
2. Patel A, et al: On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex. J Biol Chem. 2009; 284(36):24242-56.
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Research Areas :Cancer, Cell Cycle, Neurobiology