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Description :Full-length recombinant human RBBP4 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full length
Genbank Number :BC075836
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Methyltransferase Assay
Molecular Weight :~75 kDa
Gene Aliases :NURF55, RBAP48
Scientific Background :Histone-binding protein RBBP4 (RBBP4) was initially identified as one of the strongest interactions when a CREB-CREB binding protein (CBP) complex was used as bait to screen a mouse embryo cDNA library in yeast. May target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA.
1. Zhang Q, et al: Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phospho-rylated CREB. Mol Cell Biol. 2000; 20(14):4970-8.
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Research Areas :Cancer, Cell Cycle, NfkB Pathway