Rapamycin(F17-901)

Rapamycin(F17-901)

  • $226.00


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Description :mTOR inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :53123-88-9

Molecular Formula :C51H79NO13

Appearance :White crystalline powder

Melting Point :N/A

Molecular Weight :914.2

Purity :>98% (TLC: 10% CH3OH in CH2Cl2; Rf=0.51); NMR (Conforms)

Solubilization :Soluble in DMSO (50 mg/ml); or Ethanol (50 mg/ml)

Aliases :Sirolimus; Fermentation product

Storage and Stability :Storage, Stability and Shipping

Scientific Background :Potent immunosuppressant. The rapamycin-FKBP12 complex binds to and inhibits mTOR (1). Inhibits IL-2-induced activation of p70 S6 kinase (2). Extends lifespan of mice (3). Induces autophagy in a variety of cell lines (4).

References :
1. S Huang et al. Cancer Biol. Ther. 2003 2:222

2. CJ Kuo et al. Nature 1992 358:70

3. DE Harrison et al. Nature 2009 460:392

4. A Flemming et al. Nat. Chem. Biol. 2011 7:9

Molecular Structure :

Product Sheets (By Lot #) :

T2257-25.pdf

Research Areas :Cancer, Inflammation, Metabolic Disorder, AKT/PKB Pathway, Apoptosis/Autophagy, Angiogenesis