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Description :Recombinant full length human RAC2 was expressed in E.coli cells using an N-terminal His tag.
Tag :His tag
Sequence :Full length
Genbank Number :NM_002872
Specific Activity :Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Enzyme Assay, Western Blot
Molecular Weight :22 kDa
Gene Aliases :Gx, EN-7, HSPC022
Scientific Background :RAC2 is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins and is involved in a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization and the activation of protein kinases. Knockdown of the gene for both RAC1 and RAC2 completely blocks B-cell development indicating that both GTPases are required to transduce B-cell receptor (BCR) signals leading to proliferation, survival, and the upregulation of BAFF receptor (1). Furthermore, RAC2 is required for the transfer of electrons from NADPH to cytochrome b-associated FAD, then to cytochrome b heme, and finally to oxygen (2).
1.Walmsley, M. J. et al: Critical roles for Rac1 and Rac2 GTPases in B cell development and signaling. Science 302: 459-462, 2003.
2.Diebold, B. A. et al: Molecular basis for Rac2 regulation of phogocyte NADPH oxidase. Nature Immun. 2: 211-215, 2001.
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