RBBP5 Protein(R315-30H)

RBBP5 Protein(R315-30H)

  • $215.00


Description :Full-length recombinant human RBBP5 was expressed in E. coli cells using an N-terminal His tag.

Species :Human

Tag :His tag

Expression System:E.coli

Sequence :Full length

Genbank Number :NM_005057

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Methyltransferase Assay

Molecular Weight :~72 kDa

Gene Aliases :RBQ3; SWD1

Scientific Background :Retinoblastoma-binding protein 5 (RBBP5) is believed to play a crucial role in the differentiation potential, particularly along the neural lineage in embryonic stem (ES) cells, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and tri-methylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.

References :
1. Thttp://www.uniprot.org/uniprot/Q15291

2. Patel A, et al: On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex. J Biol Chem. 2009; 284(36):24242-56.

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Research Areas :Cancer, Cell Cycle, Neurobiology