RYK Protein(R28-31G)
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Description :Recombinant human RYK (255-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :255-end
Genbank Number :NM_001005861
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~66 kDa
Gene Aliases :D3S3215; JTK5; JTK5A; RYK1
Scientific Background :RYK or receptor-like tyrosine kinase is an atypical member of the family of growth factor receptor protein tyrosine kinases. RYK differs from other receptor tyrosine kinases at a number of conserved residues in the activation and nucleotide binding domains (1). RYK has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. RYK is involved in stimulating Wnt signaling pathways such as the regulation of axon path finding (2).
References :
1. Katso, R. M. et.al: Functional analysis of H-Ryk, an atypical member of the receptor tyrosine kinase family. Molec. Cell. Biol. 19: 6427-6440, 1999.
2. Lu, W. et.al: Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell 119: 97-108, 2004.
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Research Areas :Neurobiology, Receptor Tyrosine Kinases, WNT Signaling, Neurobiology, WNT Signaling, Receptor Tyrosine Kinases