RSK4, Active(R20-10G)
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Description :Recombinant full-length human RSK4 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :NM_014496
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.gel.gif)
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~112kDa
Gene Aliases :RPS6KA6
Scientific Background :RSK4 is a member of the 90-kDa ribosomal S6 kinase family which are important components of growth factor mediated stimulation of cellular proliferation, survival and differentiation. RSK4 is activated via coordinated phosphorylation by ERK and 3-phosphoinositide-dependent protein kinase-1 (PDK1) (1). RSK4 is often associated with contiguous gene syndromes consisting of X-linked deafness type 3 (DFN3), mental retardation (MRX) and choroideremia (CHM). RSK4 is most abundantly expressed in the brain and kidney (2).
References :
1. Yntema, H.G. et al:, A novel ribosomal S6-kinase (RSK4; RPS6KA6) is commonly deleted in patients with complex X-linked mental retardation. Genomics. 1999 ;15;62(3):332-43
2. Bettina, A. et al: Functional Characterization of Human RSK4, a New 90-kDa Ribosomal S6 Kinase, Reveals Constitutive Activation in Most Cell Types. J. Biol. Chem., 2005; 280, Issue 14,13304-13314
Product Sheets (By Lot #) :
Research Areas :Cancer, Inflammation, Metabolic Disorder, Cardiovascular Disease, AKT/PKB Pathway, Apoptosis/Autophagy, Angiogenesis, Ser/Thr Kinases, Cancer, Neurobiology, Inflammation, Cardiovascular Disease, ERK/MAPK Pathway, NfkB Pathway, Apoptosis/Autophagy, Ser/Thr Kinases