Anti-RSK3(R16-63R)
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Description :Rabbit Polyclonal Antibody
Species :Rabbit
Tag :
Expression System:
Sequence :
Specificity :Recognizes the RSK3 protein
Cited Applications :WB
Cross Reactivity : Human, Mouse, Rat, Bovine, Canine and Chicken
Host :Rabbit, IgG
Immunogen :Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH
Purification :Affinity Chromatography
Stability :Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Western blot of HeLa lysate showing specific immunolabeling of the ~90kDa RSK3 protein.
Scientific Background :The p90 ribosomal S6 kinases (RSK)1–4 are downstream members of the extracellular signal-regulated kinase (ERK)/MAPK cascade. RSK3 encodes a 733-amino-acid protein with a unique N-terminal region, which contains a putative nuclear localization signal (1). RSK3 mRNA is widely expressed and is activated by growth factors, serum and phorbol esters. Upon stimulation, RSK3 translocates to the cell nucleus and phosphorylates nuclear proteins. RSK3 can bind to ERK1/2 and this association increases the duration of RSK3 activation (2).
References :
1. Zhao, Y. et al: RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation. Mol Cell Biol. 1995 Aug;15(8):4353-63.
2. Roux, P. P. et al: Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity. Mol Cell Biol. 2003 Jul;23(14):4796-804.
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Research Areas :Cancer, Neurobiology, Inflammation, Cardiovascular Disease, ERK/MAPK Pathway, NfkB Pathway, Apoptosis/Autophagy