Anti-RSK1(R15-63R)
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Description :Rabbit Polyclonal Antibody
Species :Rabbit
Tag :
Expression System:
Sequence :
Specificity :Anti-RSK1 antibody recognizes the RSK1 protein.
Cited Applications :WB
Cross Reactivity :RSK1 from Human, Mouse, Rat
RSK1 from other species may also be detectable.
Host :Rabbit
Immunogen :C-LAQRRVRKLPSTTL peptide KLH conjugates
Purification :Affinity purified by peptide C-LAQRRVRKLPSTTL on agarose from rabbit serum
Stability :Store at 4°C (add 0.1% NaN3) for several months, and at -20°C for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For optimal performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data :Representative western blot (1:2000) using 5µg, 10µg, and 20µg of from HeLa cell lysate.
Scientific Background :RSK1 is a member of the RSK (ribosomal S6 kinase) family that are growth factor-regulated serine/threonine kinases. RSK1 contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signaling pathway. RSK1 encodes a predicted 735-amino acid protein containing 2 distinct consensus ATP-binding site sequences. RSK1 transcript is present in lymphocytes, skeletal muscle, liver, and adipose tissue (1). RSKs are implicated in the activation of the mitogen-activated kinase (MAPK) cascade and the stimulation of cell proliferation and differentiation (2).
References :
1. Moller, D E. et al: Human rsk isoforms: cloning and characterization of tissue-specific expression. Am. J. Physiol. 266: C351-C359, 1994.
2. Gross, S D. et al: Induction of metaphase arrest in cleaving Xenopus embryos by the protein kinase p90(Rsk). Science 286: 1365-1367, 1999.
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Research Areas :Cancer, Neurobiology, Inflammation, Cardiovascular Disease, ERK/MAPK Pathway, NfkB Pathway, Apoptosis/Autophagy, Cancer, Neurobiology, Inflammation, Cardiovascular Disease, ERK/MAPK Pathway, NfkB Pathway, Apoptosis/Autophagy