PX-866(P27-900)

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Description :PI3K inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :502632-66-8

Molecular Formula :C29H35NO8

Appearance :Orange powder

Melting Point :N/A

Molecular Weight :525.6

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (25 mg/ml)

Aliases :(1E,4S,4aR,5R,6aS,9aR)-5-(acetyloxy)-1-[(di-2-propen-1-ylamino) methylene]-4,4a,5,6,6a,8,9,9-a-octahydro-11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-cyclopenta [5,6] naphtha [1,2-c] pyran-2,7,10(1H)-trione

Storage and Stability :Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 2 months.

Scientific Background :Inhibits PI3-kinase with selectivity for p110alpha (IC50=0.1 nM). Displays antitumor activity. Irreversible. Cell permeable.

References :
1. NT Ihle et al. Mol. Cancer Ther. 2004 3:763

Molecular Structure :

Product Sheets (By Lot #) :

T2257-36.pdf

Research Areas :Cancer, Neurobiology, Inflammation, Metabolic Disorder, Cardiovascular Disease, AKT/PKB Pathway, NfkB Pathway, WNT Signaling, Apoptosis/Autophagy, Angiogenesis, Invasion/Metastasis, Lipid Kinases