PTPRJ (CD148), Active(P56-21G)
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Description :Recombinant full length human PTPRJ was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full length
Genbank Number :NM_002843
Specific Activity :Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Phosphatase Assay, Western Blot
Molecular Weight :65 kDa
Gene Aliases :CD148; DEP1; HPTPeta; R-PTP-ETA; SCC1
Scientific Background :Receptor-type tyrosine-protein phosphatase eta or protein-tyrosine phosphatase receptor type J (R-PTP-J or CD148) are membrane protein tyrosine phosphatase initially identified on the membrane of HeLa and F-36P human leukemic cells. It contains an extracellular portion compromised of eight fibronectin III domains, a transmembrane segment and an intracytoplasmic tail which contains a single PTP domain. The presence of fibronectin III motifs in the extracellular domain suggest its possible involvement in cell adhesion processes.
1. Ostman, A., et al: Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density. Proc Natl Acad Sci USA, 91. 9680-9684, 1994.
2. Honda, H., et al: Molecular cloning, characterization and chromosomal localization of a novel protein-tyrosine phosphatase, HPTPn. Blood, 84. 4186-4194, 1994.
3. Gayà A, et al: CD148, a new membrane tyrosine phosphatase involved in leukocyte
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Research Areas :Cancer, Inflammation, Phosphatases