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PTPRF (LAR), Active(P53-21G)

PTPRF (LAR), Active(P53-21G)

  • $226.00


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Description :Recombinant human PTPRF (1275-1897) was expressed in E. coli cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:E.coli

Sequence :1275-1897

Genbank Number :NM_002840

Specific Activity :Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Phosphatase Assay, Western Blot

Molecular Weight :~93 kDa

Gene Aliases :LAR

Scientific Background :PTPRF or LAR is a member of the protein tyrosine phosphatase family with an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains (1). PTPRF has been shown to function in the regulation of epithelial cell-cell contacts at adherents junctions as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance (2).

References :
1. Ahmad, F. et al: Functional association between the insulin receptor and the transmembrane protein-tyrosine phosphatase LAR in intact cells. J. Biol. Chem. 272: 448-457, 1997.

2. Tsujikawa, K. et al: Distinct functions of the two protein tyrosine phosphatase domains of LAR (leukocyte common antigen-related) on tyrosine dephosphorylation of insulin receptor. Molec. Endocr. 15: 271-280, 2001. J. 2003 Aug 15;22(16):4121-31.

Product Sheets (By Lot #) :

P153-1.pdf

T981-5.pdf

R2856-7a.pdf

Research Areas :Cancer, Invasion/Metastasis, Phosphatases, Cancer, Invasion/Metastasis, Phosphatases