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Description :Recombinant human PTPRE (75-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Genbank Number :BC050062
Specific Activity :Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Phosphatase Assay, Western Blot
Molecular Weight :~91 kDa
Gene Aliases :PTPE, P-PTP-epsilon, HPTPE, R-PTP-EPSILON, RP11-380J17.1, DKFZp313F1310, FLJ57799, FLJ58245
Scientific Background :PTPRE or protein tyrosine phosphatase receptor type E is a member of the protein tyrosine phosphatase (PTP) family. This family of proteins are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPRE is highly expressed in brain and testis (1). The regulatory roles of this PTP in Ras related signal transduction pathways, cytokines induced signaling, as well as the activation of voltage-gated K+ channels have been identified. PTPRE has a transmembrane segment and a cytoplasmic region containing duplicated PTPase domains (2).
1. Yi, T. et.al: Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification. Blood 78: 2222-2228, 1991.
2. Krueger, N. X. et.al: Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. EMBO J. 9: 3241-3252, 1990.
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Research Areas :Cancer, Inflammation, Phosphatases, Cancer, Invasion/Metastasis, Phosphatases