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PTPN7 (LC-PTP), Active(P34-20G)

PTPN7 (LC-PTP), Active(P34-20G)

  • $226.00


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Description :Recombinant full length human PTPN7 was expressed in E.coli cells using a N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:E.coli

Sequence :Full Length

Genbank Number :NM_002832

Specific Activity :Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Phosphatase Assay, Western Blot

Molecular Weight :~67 kDa

Gene Aliases :LC-PTP, LPTP, HEPTP, PTPNI, BPTP-4

Scientific Background :PTPN7 gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells (1). The noncatalytic N-terminus of this PTP can interact with MAP kinases and negatively regulates ERK2 and p38 MAP-kinases activity (2). The PTPN7 was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway (3).

References :
1. Adachi, M. et al: Protein-tyrosine phosphatase expression in pre-B cell NALM-6. Cancer Res. 52: 737-740, 1992.

2. Pettiford, S M. et al: The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP. Oncogene. 2000 Feb 17;19(7):858-69.

3. Oh-hora, M. et al: Direct .suppression of TCR-mediated activation of extracellular signal-regulated kinase by leukocyte protein tyrosine phosphatase, a tyrosine-specific phosphatase. J Immunol. 1999 Aug 1;163(3):1282-8.

Product Sheets (By Lot #) :

B024-1.pdf

Research Areas :Cancer, Neurobiology, Metabolic Disorder, Phosphatases, Cancer, Inflammation, Metabolic Disorder, JAK/STAT Pathway, WNT Signaling, Invasion/Metastasis, Phosphatases