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PRPF19 Protein(P270-30G)

PRPF19 Protein(P270-30G)

  • $215.00


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Description :Recombinant human PRPF19 (2-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :2-end

Genbank Number :NM_014502

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Western Blot

Molecular Weight :~74 kDa

Gene Aliases :PSO4; SNEV; PRP19; UBOX4; hPSO4; NMP200

Scientific Background :PRPF19 or pre-mRNA-processing factor 19 is the human homolog of yeast Pso4. PRPF19 is a gene essential for cell survival, DNA repair and association with terminal deoxynucleotidyl transferase (1). PRPF19 forms a stable complex with SETMAR (Metnase) which is a SET and transposase fusion protein in humans and plays a positive role in double-strand break (DSB) repair. PRPF19 mediates association of SETMAR with sites of DNA damage (2). SNEV is an orthologue of PRPF19 and is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assembly.

References :
1. Mahajan, K. N. et.al: Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase. Proc. Nat. Acad. Sci. 100: 10746-10751, 2003.

2. Beck, B. D. et.al: Human Pso4 is a Metnase (SETMAR)-binding partner that regulates Metnase function in DNA repair. J. Biol. Chem. 283: 9023-9030, 2008.

Product Sheets (By Lot #) :

O988-2.pdf

Research Areas :Apoptosis/Autophagy, Cell Cycle, Apoptosis/Autophagy, Cell Cycle