PRDM2 (KMT8) Protein(P333-31G)
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Description :Recombinant PRDM2 (KMT8) (1-340) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Genbank Number :NM_012231
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Methyltransferase Assay
Molecular Weight :80 kDa
Gene Aliases :HUMHOXY1; KMT8; MTB-ZF; RIZ; RIZ1; RIZ2
Scientific Background :PRDM2 is a histone methyltransferase that specifically methylates lysine-9 of histone H3. PRDM2 is a retinoblastoma protein-interacting zinc finger protein and a tumor suppressor. Loss of PRDM2 activity through loss of mRNA expression, frameshift, deletion, and missense mutation is commonly found in many types of human cancers (1, 2).
1. Du, Y., et al. Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone/protein methyltransferase superfamily. Cancer Res. 61(22):8094-9, 2001.
2. Kim, K.C., et al. Inactivation of a histone methyltransferase by mutations in human cancers. Cancer Res. 63(22):7619-23, 2003.
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Research Areas :Cancer, Neurobiology