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Description :Recombinant full-length human PP2Cgamma was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :NM_177983
Specific Activity :Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Phosphatase Assay, Western Blot
Molecular Weight :~105 kDa
Gene Aliases :PP2C-GAMMA, PP2CG, PPM1G, PPP2CG, MGC1675, MGC2870
Scientific Background :PP2Cγ is a member of the PP2C family of Ser/Thr protein phosphatases which are known to be negative regulators of cell stress response pathways. PP2C gamma is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome (1). PP2C gamma is highly expressed in testis, skeletal muscle, and heart (2). PP2C gamma also plays a main role in regulating cell cycle progression.
1. Murray, M. V. et.al: The type 2C Ser/Thr phosphatase PP2C-gamma is a pre-mRNA splicing factor. Genes Dev. 13: 87-97, 1999.
2. Travis, S. M. et.al: PP2C-gamma: a human protein phosphatase with a unique acidic domain. FEBS Lett. 412: 415-419, 1997.
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Research Areas :Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Metabolic Disorder, Phosphatases, Ser/Thr Kinases, Cancer, Metabolic Disorder, Cardiovascular Disease, ERK/MAPK Pathway, Cell Cycle, Ser/Thr Kinases, Phosphatases