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  • $165.00


Description :SRC family kinase inhibitor

Species :

Tag :

Expression System:

Sequence :

CAS Registry Number :172889-27-9

Molecular Formula :C15H16ClN5

Appearance :Off-white solid

Melting Point :N/A

Molecular Weight :301.8

Purity :>98% (TLC); NMR (Conforms)

Solubilization :May be dissolved in DMSO (25 mg/ml); or ethanol (3 mg/ml, warm)

Aliases :3-(4-chlorophenyl) 1-(1,1-dimethylethyl)-1H-pyrazolo [3,4-d] pyrimidin-4-amine

Storage and Stability :Store desiccated as supplied at -20oC for up to 2 years. Store stock solutions at -20oC for one month.

Scientific Background :Potent and selective Src family kinase inhibitor. Inhibits Lck (IC50=4 nM), Fyn (IC50=5 nM), and Hck (IC50=5 nM).Shows weaker inhibition of EGFR (IC50=480 nM) and no inhibition of ZAP-70 (IC50=100 uM) and JAK2 (IC50=50 uM). Useful for probing the involvement of Src family tyrosine kinases in cellular signaling.

References :
1. F. Carlomagno et al.; J. Clin. Endocrinol. Metab. 2003 8:1897

2. J.K. Chen et al.; J Biol Chem. 2000 275:13789

3. M. Yoshizumi et al.; J. Biol. Chem. 2000 275:11706

4. J.H. Hanke et al.; J. Biol. Chem. 1996 271:695

Molecular Structure :

Product Sheets (By Lot #) :


Research Areas :Angiogenesis, Apoptosis/Autophagy, Cancer, Cytoplasmic Tyrosine Kinases, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, JAK/STAT Pathway, Cancer, Inflammation, ERK/MAPK Pathway, JAK/STAT Pathway, Apoptosis/Autophagy, Angiogenesis, Invasion/Metastasis, Cytoplasmic Tyrosine Kinases