PLK4, Active(P44-11G)

PLK4, Active(P44-11G)

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Description :Recombinant human PLK4 (1-836) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :1-836

Genbank Number :NM_014264

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~140 kDa

Gene Aliases :SAK, STK18

Scientific Background :PLK4 or polo-like kinase 4 is a member of the polo family of serine/threonine protein kinases which localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. The overexpression of PLK4 triggered the simultaneous formation of multiple procentrioles around each preexisting centriole which resulting in centriole amplification and thus, Plk4-induced centriole biogenesis in human cells (1).The reduced Plk4 gene dosage increases the probability of mitotic errors and cancer development (2).

References :
1. Kleylein-Sohn, J. et.al: Plk4-induced centriole biogenesis in human cells. Dev. Cell 13: 190-202, 2007.

2. Ko, M. A. et.al: Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis. Nature Genet. 37: 883-888, 2005.

Product Sheets (By Lot #) :

S310-1.pdf

S299-4.pdf

T885-1.pdf

Z1348-1.pdf

P1833-8.pdf

H2726-12.pdf

E3019-9.pdf

S3522-1.pdf

Research Areas :Cancer, Cell Cycle, Ser/Thr Kinases, Cancer, Cell Cycle, Ser/Thr Kinases