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PKD2 (G870E), Active(P76-12CG)

PKD2 (G870E), Active(P76-12CG)

  • $226.00


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Description :Recombinant full-length human PKD2 (G870E) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full length (G870E)

Genbank Number :NM_016457

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay

Molecular Weight :~130 kDa

Gene Aliases :HSPC187; nPKC-D2; PRKD2

Scientific Background :PKD2(G870E) is a glycine to glutamic acid mutation at 870 aa in PKD2 and appears as a somatic mutation in gastric adenocarcinoma samples. PKD2 is a member of the polycystin protein family and is involved in calcium transport and calcium signaling in renal epithelial cells. PKD2 interacts with polycystin 1 and this complex may be partners in a common signaling cascade involved in tubular morphogenesis. PKD2 may function as a chaperone-like molecule, which may prevent ERAD of PKD2 (1). PKD2 form an interaction network with PKD1 as the rate-limiting component (2).

References :
1. Gao, H.et.al: PRKCSH/80K-H, the protein mutated in polycystic liver disease, protects polycystin-2/TRPP2 against HERP-mediated degradation. Hum. Molec. Genet. 19: 16-24, 2010.

2. Fedeles, S. V.et.al: A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation. Nature Genet. 43: 639-647, 2011.

Product Sheets (By Lot #) :

J558-3.pdf

Research Areas :Apoptosis/Autophagy, Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, NfkB Pathway, PKA/PKC Pathway, Ser/Thr Kinases, Neurobiology, Cardiovascular Disease, ERK/MAPK Pathway, NfkB Pathway, PKA/PKC Pathway, Apoptosis/Autophagy, Ser/Thr Kinases