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PKC beta II, Active(P63-10G)

PKC beta II, Active(P63-10G)

  • $160.00


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Description :Recombinant full-length human PKCbeta II was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full Length

Genbank Number :NM_002738

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. Refer to lot specific technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~105 kDa

Gene Aliases :PRKCB1; PKCB2; PRKCB1; PRKCB (X07109)

Scientific Background :PKCβ II is a member of the protein kinase C (PKC) family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol and phosphorylate a wide variety of protein targets known to be involved in diverse cellular signaling pathways (1). PKCβ II has been reported to be involved in many different cellular functions such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption (2).

References :
1. Greenham, J. et al: Elucidation of the exon-intron structure and size of the human protein kinase C beta gene (PRKCB). Hum. Genet. 103: 483-487, 1998.

2. Su, T T. et al: PKC-beta controls I-kappa-B kinase lipid raft recruitment and activation in response to BCR signaling. Nature Immun. 3: 780-786, 2002.

Product Sheets (By Lot #) :

I172-2.pdf

I220-2.pdf

Research Areas :Neurobiology, Cardiovascular Disease, ERK/MAPK Pathway, NfkB Pathway, PKA/PKC Pathway, Apoptosis/Autophagy, Ser/Thr Kinases, Neurobiology, Cardiovascular Disease, ERK/MAPK Pathway, NfkB Pathway, PKA/PKC Pathway, Apoptosis/Autophagy, Ser/Thr Kinases