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Description :Recombinant full-length human PIP5K1B was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full length
Genbank Number :NM_003558
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay
Molecular Weight :96 kDa
Gene Aliases :MSS4; STM7
Scientific Background :PIP5K1B (phosphatidylinositol-4-phosphate 5-kinase, type I, beta) is a member of the phosphatidylinositol-4-phosphate 5-kinase family. PIP5K1B gene contains 17 exons and spans more than 300 kb. The seventeenth exon was found by RT-PCR, and are derived from the 3-prime untranslated region of the PRKACG gene which is located on 9q13 approximately 3 kb downstream of the STM7.I 3-prime untranslated region (1). The overexpression of PIP5K1B in COS-7 cells induces an increase in short actin fibers and a decrease in actin stress fibers(2).
1. Pook, M. A.et.al: Exon-intron structure of a 2.7-kb transcript of the STM7 gene with phosphatidylinositol-4-phosphate 5-kinase activity. Genomics 42: 170-172, 1997.
2. Ishihara, H.et.al: Type I phosphatidylinositol-4-phosphate 5-kinases: cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family. J. Biol. Chem. 273: 8741-8748, 1998.
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Research Areas :AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Lipid Kinases, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling