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Description :Recombinant full-length human PIP4K2C was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full length
Genbank Number :BC028596
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay
Molecular Weight :75 kDa
Gene Aliases :PIP5K2C; FLJ22055
Scientific Background :PIP4K2C (also known as phosphatidylinositol-5-phosphate 4-kinase, type II, gamma) is a member of the PIP kinase family that plays an important role in a wide variety of cell functions (1). PIP4K2C is found in the cytosol and surrounding plasma membrane and its presence in the endoplasmic reticulum seems to be a prerequisite for PIP2 synthesis. PIP4K2C play an important role in the production of phosphatidylinositol bisphosphate (PIP2) in the endoplasmic reticulum (2).
1. Heck JN. et.al: A conspicuous connection: structure defines function for the phosphatidylinositol-phosphate kinase family. Crit. Rev. Biochem. Mol. Biol. 2007 42:15-3.
2. Kanaho Y. et.al: The phosphoinositide kinase PIP5K that produces the versatile signaling phospholipid PI4,5P(2) Biol. Pharm. Bull. 2007 30:1605-9.
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Research Areas :AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Lipid Kinases, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling