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PIM2, Active(P36-10G)

PIM2, Active(P36-10G)

  • $226.00


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Description :Recombinant full-length human PIM2 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full Length

Genbank Number :NM_006875

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Kinase Assay, Western Blot

Molecular Weight :~61 kDa

Scientific Background :PIM2 is a serine threonine kinase that is present in all tissues, being most abundant in hematopoietic tissues, spleen, thymus, and peripheral blood leukocytes, as well as in testis, small intestine, and colon (1). It is highly expressed in human leukemic, lymphoma and colorectal adenocarcinoma cell lines. This suggests a role for PIM2 in proliferating cells as well as during meiosis. Similar to PIM1, PIM2 also acts as a pro-survival kinase and BAD protein is a legitimate PIM2 substrate (2).

References :
1. Baytel, D. et al; The human Pim-2 proto-oncogene and its testicular expression. Biochim. Biophys. Acta 1442: 274-285, 1998.

2. Yan, B. et al: The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death. J Biol Chem. 2003 Nov 14;278(46):45358-67.

Product Sheets (By Lot #) :

S179-3.pdf

Research Areas :Cancer, Neurobiology, Inflammation, Apoptosis/Autophagy, Cellular Stress, Ser/Thr Kinases, Cancer, Neurobiology, Inflammation, Apoptosis/Autophagy, Cellular Stress, Ser/Thr Kinases